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Materials Science and Engineering: C
Vol. 49, 2015, Pages: 799–806

Bioprocess intensification of antibiotic production by Streptomyces coelicolor A3(2) in micro-porous culture

T.M. Ndlovu, A.C. Ward, J. Glassey, J. Eskildsen, G. Akay

NUTRISS Limited, INEX, Herschel Annex, Kings Road, Newcastle upon Tyne NE1 7RU, UK.


A novel functionalized micro-porous matrix was developed with well-controlled physicochemical proprieties such as pore size and surface chemistry. The matrix was used as a solid support in the growth of “Streptomyces coelicolor” A3(2) to enhance the production of antibiotics. The results shown support a higher production of prodigiosin and actinorhodin with overall production increase of 2–5 and 6–17, respectively, compared to conventional submerged liquid culture, offering a potential improvement in volumetric productivity.

Scanning Electron Microscopy was used to evaluate pore size as well as bacterial adhesion, penetration, proliferation and migration within the micro-porous matrix.

Graphical abstract

Keywords: Polymerisation; Functionalization; Micro-porous matrix growth; Submerged growth; “Streptomyces coelicolor” A3(2); Antibiotic.

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